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In cases of missed doses of thiazolidinediones, such as pioglitazone and rosiglitazone, the recommended action is to skip the missed dose. These medications are typically taken with meals to enhance absorption and minimize gastrointestinal side effects. If a meal is missed, taking the medication on an empty stomach may not provide the intended benefit, and it may increase the risk of side effects.

When managing diabetes with medication, it is essential to maintain a consistent routine. The general principle for missed doses of thiazolidinediones is to take them during regular meal times. Consuming them when the meal is not being eaten does not align with their intended use and could potentially lead to fluctuations in blood sugar levels.

Skips on doses should not be followed by taking the next dose double or otherwise increasing the dose without consulting a healthcare provider. This could lead to adverse effects or a sudden drop or spike in blood glucose levels. Consulting a healthcare provider for further guidance is only necessary if there are concerns regarding the adjustments in the medication regimen that need to be addressed.

Therefore, when managing thiazolidinediones, skipping a missed dose when a meal is missed is the correct action to ensure safety and effectiveness in diabetes management.