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In patients with atrial fibrillation who are being treated with Coumadin (Warfarin), the targeted International Normalized Ratio (INR) is typically between 2 and 3. This range is considered optimal for preventing thromboembolic events, such as strokes, while minimizing the risk of bleeding complications associated with anticoagulant therapy.

The rationale behind this target INR is based on clinical studies and guidelines that demonstrate this range effectively balances the benefits of anticoagulation in preventing clots against the risks of excessive bleeding. An INR below 2 may not provide adequate anticoagulation to prevent thrombus formation, while an INR above 3 significantly increases the risk of serious bleeding events, including intracranial hemorrhage.

Thus, maintaining the INR within the 2-3 target range allows for effective management of atrial fibrillation with an appropriate safety profile, making it the recommended therapeutic range for these patients.